Salesforce Provider Synaptic Raises $5M Amid Focus on AI Services
Baltimore-based Synaptic Era, a Salesforce provider, is leveraging a recent $5 million seed funding round to build a business model on its emerging solution-as-a-service and agent-as-a-service operations, with CEO Bill Karpovich pushing an outcome-based agenda, CRN reported last week.
“Who wants to buy an hour? An hour is an input,” said Karpovich, who took control of the company in 2020 after becoming the first outside investor in the firm. Customers “want to buy an output. (They are) going to buy the outcome – and that’s where it’s evolving,” he said in an interview with the industry publication.
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Frasca in Boulder wins James Beard Award for Best Restaurant
The James Beard Foundation (JBF) Awards swept Chicago into a frenzy on Monday, June 16, at the Lyric Opera. Of all the Colorado contestants, upscale Italian restaurant Frasca Food and Wine in Boulder was named Outstanding Restaurant. This makes the restaurant’s collective fourth James Beard Award. Though there were six finalists headed into the final night of the ceremony, most of the Colorado contestants lost out.
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Our Beloved Friend and Investor, Harold Tanner, dies at 93
Harold Tanner ’52, chairman emeritus of the Cornell Board of Trustees – who helped usher in an era of financial stability as a co-chair of Cornell’s first billion-dollar endowment campaign and served as board chair during the transformative shift of all first-year students to North Campus residences – died June 14 in New York. He was 93.
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2024 AMGA Annual Report
The AMGA mission drives a robust set of core competencies—education, standard setting, and advocacy—that serve to advance the AMGA community and the guiding industry. The mission positions the organization to tackle big industry challenges while also serving individual guides with career development and community.
In 2024, the AMGA executed high-impact initiatives that touched on all three areas of the mission. On the advocacy front, the passage of the EXPLORE Act in December 2024 was a landmark achievement for guides that will give rise to a new era of increased access and streamlined permitting. In the realm of education, the AMGA redesigned the entrance to the Alpine Guide Program to provide terrain-specific training in snow and glacier guiding, and alpine rock guiding. The new programs will enable guides to quickly gain qualification to work in the classic alpine ranges and will better meet the needs of AMGA Accredited Businesses. As a standard-setting organization, the AMGA made important refinements to the AMGA Scope of Practice including the introduction of a terrain complexity scale.
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Small molecule GLP-1s in Science Magazine (featuring Ambrosia!)
Drugs that mimic glucagonlike peptide-1 (GLP-1), such as semaglutide—marketed as Ozempic or Wegovy—have revolutionized the treatment of obesity and type 2 diabetes, but they have major drawbacks. “[They] are expensive to manufacture, they have to be refrigerated, and they often have to be injected because they cannot go through the gastrointestinal tract without being degraded,” explains Alejandra Tomas, a cell biologist at Imperial College London who studies the cellular receptor GLP-1 drugs target. That’s all because they consist of peptides, or long chains of amino acids.
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Opanga Secures Strategic Funding from Boulder Ventures, Cisco Investments, Grayhawk Capital and Trilogy Equity Partners
SEATTLE – April 15, 2025 – Opanga, a global leader in AI-powered network optimization solutions, today announced it has received strategic investments from Boulder Ventures, Cisco Investments, the global corporate venture investment arm of Cisco, Grayhawk Capital and Trilogy Equity Partners.
This financing will support future product development, sales and marketing for Opanga’s AI-driven platform, RAIN, as the company continues expanding its deployments with global telecom operators to enhance network optimization and improve real-time customer experience across the telecom industry.
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Tariff Chaos is a C-Suite Problem
With the US imposing harsh protectionist measures via aggressive import taxes, American and global manufacturers are racing to find solutions and responses. Margins are under siege. Strategic sourcing is being rewritten in real time.
Here’s the hard truth: if you’re waiting for your supply chain team or ERP vendor to sort this out, you’re already behind.
This is not just a compliance problem. It’s a C-Suite problem. And it demands a C-Suite solution.
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Black Bear Energy's 10th Anniversary!
Today Black Bear Energy Inc. turns ten! We are humbled to represent over 100 of the most forward-thinking real estate owners, honored to work with many leading partners and privileged to be a part of this industry.
My biggest learning over this past decade; the importance of culture to the success of an organization. Thank you to everyone who has helped shape this company and continues to do so.
We love what we do and we are just getting started. ONWARD!!
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Mineralys Therapeutics Announces Positive Topline Results from Launch-HTN and Advance-HTN Pivotal Trials of Lorundrostat for the Treatment of Uncontrolled or Resistant Hypertension
RADNOR, Pa., March 10, 2025 (GLOBE NEWSWIRE) -- Mineralys Therapeutics, Inc. (Nasdaq: MLYS), a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension, chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone, today announced positive topline data from its pivotal Launch-HTN Phase 3 and pivotal Advance-HTN Phase 2 trials evaluating the efficacy and safety of lorundrostat for the treatment of uncontrolled hypertension (uHTN) or resistant hypertension (rHTN). Both trials successfully achieved statistical significance and were clinically meaningful in their pre-specified primary efficacy endpoints and demonstrated a favorable safety and tolerability profile.
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